package main import ( "bufio" "encoding/gob" "flag" "fmt" "io" "log" "net/http" _ "net/http/pprof" ) type filterer struct { output io.Writer } func (cmd *filterer) RunCommand(prog string, args []string, stdin io.Reader, stdout, stderr io.Writer) int { var err error defer func() { if err != nil { fmt.Fprintf(stderr, "%s\n", err) } }() flags := flag.NewFlagSet("", flag.ContinueOnError) flags.SetOutput(stderr) pprof := flags.String("pprof", "", "serve Go profile data at http://`[addr]:port`") maxvariants := flags.Int("max-variants", -1, "drop tiles with more than `N` variants") mincoverage := flags.Float64("min-coverage", 1, "drop tiles with coverage less than `P` across all haplotypes (0 < P ≤ 1)") maxtag := flags.Int("max-tag", -1, "drop tiles with tag ID > `N`") err = flags.Parse(args) if err == flag.ErrHelp { err = nil return 0 } else if err != nil { return 2 } cmd.output = stdout if *pprof != "" { go func() { log.Println(http.ListenAndServe(*pprof, nil)) }() } log.Print("reading") cgs, err := ReadCompactGenomes(stdin) if err != nil { return 1 } log.Printf("reading done, %d genomes", len(cgs)) log.Print("filtering") ntags := 0 for _, cg := range cgs { if ntags < len(cg.Variants)/2 { ntags = len(cg.Variants) / 2 } if *maxvariants < 0 { continue } maxVariantID := tileVariantID(*maxvariants) for idx, variant := range cg.Variants { if variant > maxVariantID { for _, cg := range cgs { if len(cg.Variants) > idx { cg.Variants[idx & ^1] = 0 cg.Variants[idx|1] = 0 } } } } } if *maxtag >= 0 && ntags > *maxtag { ntags = *maxtag for i, cg := range cgs { if len(cg.Variants) > *maxtag*2 { cgs[i].Variants = cg.Variants[:*maxtag*2] } } } if *mincoverage < 1 { mincov := int(*mincoverage * float64(len(cgs)*2)) cov := make([]int, ntags) for _, cg := range cgs { for idx, variant := range cg.Variants { if variant > 0 { cov[idx>>1]++ } } } for tag, c := range cov { if c < mincov { for _, cg := range cgs { if len(cg.Variants) > tag*2 { cg.Variants[tag*2] = 0 cg.Variants[tag*2+1] = 0 } } } } } log.Print("filtering done") w := bufio.NewWriter(cmd.output) enc := gob.NewEncoder(w) log.Print("writing") err = enc.Encode(LibraryEntry{ CompactGenomes: cgs, }) if err != nil { return 1 } log.Print("writing done") err = w.Flush() if err != nil { return 1 } return 0 }